Tag Archives: cANCER

Dear Senator . . .

Plea from a cancer survivor and scientist to save the ACA and science funding

 

Dear Senator,

My name is Kiran Dhillon and I live in Seattle, WA (98102). I am writing to ask you to help save the Affordable Care Act and to strongly support increased funding for scientific research.

In March 2015, I was diagnosed with breast cancer. The news was devastating but I powered through surgery, chemotherapy and radiation. I even met you at a fundraiser for you in West Seattle soon after I had lost my hair to chemotherapy. At the time, I was a scientist at the Fred Hutch, studying chemotherapy resistance in breast and ovarian cancers of all things. I had excellent insurance and acquired only a few thousand dollars in debt from medical bills. Now as I wait for my 2 year mammogram on March 10, I find myself filled with an enormous amount of anxiety. My cancer was found early so the prognosis is very good but I still can’t help being nervous before the big test. This time around, the prospect of repeal of the Affordable Care Act has added another dimension to the anxiety. I have insurance now but if I ever had a recurrence, would I be denied coverage due to preexisting conditions if President Trump and Republicans had their way with the repeal of the ACA? This thought terrifies me. Would I have to make decisions based on my financial ability instead of my medical needs? Would I become a burden for my family?

As a scientist and someone who now promotes scientific research as the Director of Scientific Programs for the Rivkin Center for Ovarian Cancer, I’m also alarmed at the prospect of reduced funding for scientific research. Men and women who are currently battling or have survived the horrible ordeal of cancer are depending on scientists across the nation to continue to work hard until we have a cure for these deadly diseases.

The United States has been the leader of research and innovation since the time of Benjamin Franklin—a tradition that continues today. I believe there are (at least) two major factors that have contributed to our success and both are under threat with the new administration. First, we invest more at the federal level on research and development than any other country. Second, our immigrant past and present ensure a diversity of ideas and approaches that are required to solve difficult scientific, medical and engineering challenges. The policies and tweets of the current White House administration threaten both federal funding for research and development and immigration and diversity. We will surely not remain leaders in innovation and research if these trends continue.

Senator, we need you and your colleagues in both the Senate and the House to fight for us. Fight for cancer survivors like me. Fight for the ACA. Fight for science. Fight for immigrants. We also promise to do our part. As you have seen we have organized ourselves. You and your colleagues will hear from us. We will provide you the public support you need to help defend our freedoms and rights to equality, healthcare and a healthy environment. Fight for America.

I appreciate your help and ask that you please send me a response with a commitment to protecting the ACA and funding for research. Thank you for your time and considering my request.

Sincerely,

KD Signature

Kiran Dhillon, PhD

Schedule for 3rd Annual Seattle Genetic Instability and Cancer Symposium Announced

SGICS LogoWe organized the first Seattle Genetic Instability and Cancer Symposium (SGICS) three years ago as a means to bring together local (Seattle-based) scientific talent focused on, as the title implies, genetic instability and cancer. The objective was to learn about local (unpublished) research and meet the researchers in an effort to increase dialog and collaboration. This year, marking the 3rd year of SGICS, will feature 14 short talks and 22 poster presentations selected from submitted abstracts. The talks and posters will focus on the following areas of research: Genetic Engineering & Cancer Biology, Chromosome Metabolism, DNA Damage Response, Genetic Instability & DNA Repair Disorders.

Dr. Aziz Sancar, Sarah Graham Kenan Professor of Biochemistry and Biophysics at the  University of North Carolina, Chapel Hill, is this year’s Keynote Speaker. Dr. Sancar will be talking about his extraordinary work on ‘Genome-wide analysis of human global and trancription-coupled excision repair of UV damage at single-nucleotide resolution.’

SGICS is a grassroots event organized by a team of graduate students and postdocs from Fred Hutch and UW School of Medicine. SGICS will be held on June 15th, 2015, from 8:30am to 6:30pm at the Orin Smith Auditorium at the South Lake Union Campus of the University of Washington. Check out the website for the final schedule and more information.

Personalized medicine changing what it means to ‘do the best we can’ for patients

The Institute for Systems Biology in Seattle held a conference this week that focused on systems biology and cancer. Experts from all over the country were brought together  to share their work on how biological and clinical data derived from a single patient or big data derived from thousands of patients can be analyzed, integrated and, ultimately, used to treat that patient or others like him or her. The technological developments of the past decade and half allow us to generate large amounts of data from any given individual. These data include the individual’s genetic sequence, the levels of different genes being expressed in their cells, and other clinically relevant information. A big challenge for physicians is how to bring the benefits from these technological advances into the clinic to benefit patients.

During the conference, Dr. Tony Blau, a physician scientist from the University of Washington, described how having access to large amounts of data has changed what  ‘doing the best we can’ for a patient means since he first started treating cancer. He urged that it is time to bridge the enormous the gap between the rate of growth of current technological advancements and the rate at which these advancements are making it to the clinic. He discussed some of his own efforts toward this goal in a TEDx talk earlier this year. Check it out for yourself!

 

Adapted from Dr. Tony Blau's TEDx Tacoma talk and presentation at the ISB Systems Biology and Cancer Symposium, April 2014
Adapted from Dr. Tony Blau’s TEDx Tacoma talk and presentation at the ISB Systems Biology and Cancer Symposium, April 2014

Message from a princess: Cancer is a global health problem

When I think of global health issues pertinent to the developing world, I generally think of infectious diseases–like malaria, HIV and tuberculosis. Cancer usually doesn’t come to mind–it’s only a problem for the developed world, right? Wrong.

After attending a lecture today by Her Royal Highness Princess Dina Mired of Jordan (King Hussein Cancer Foundation), it is clear to me that cancer is a global health problem. The lecture also included remarks by  Dr. Julie Gralow (Seattle Cancer Care Alliance oncologist and Jill Bennett Endowed Professor in Breast Cancer), Dr. Julio Frenk, (Dean, Harvard School of Public Health and former Health Minister of Mexico) and Dr. Felicia Knaul (Harvard Medical School). It turns out that about 54% of cancer diagnoses and 64% of cancer deaths in the world come from developing countries. By 2030, the percentage cancer deaths that come from developing countries is predicted to go up to 70%. What’s tragic is that many of these deaths are preventable! For example, Acute Lymphoblastic Leukemia has 80-90% survival rate in the western world, while the survival rate in developing countries is around 10%.

CANCER IN DEV

Another example is cervical cancer. While cervical cancer related mortality has gone down in the US due to extensive screening, it still a major problem in developing countries. Several years ago, scientists (including some who work across the hall from me) developed a vaccine that prevents a vast majority of cervical cancer by targeting the Human papilloma virus (HPV). HPV infection is the leading cause of cervical cancer. A recent study (written about in the New York Times today) shows that the incidence of HPV infection has significantly decreased in teenagers since the introduction of the HPV vaccine. This is great news for the US as we can also expect rates of cervical cancer to go down. But what about poorer countries? Under the direction of Dr. Julio Frenk, Mexico has implemented health reforms that provide the HPV vaccine free to school-aged girls. This practice is not widespread in most low and mid-income countries though it can help prevent cervical cancer.

Additionally, a fact of life with cancer often is the necessity for palliative care–end of life care that generally involves management of pain. While availability of medicines to manage pain is good in the US, Canada, Australia and the EU, it is a huge problem in developing countries. Sadly, not only will more people die of cancer in developing countries but they will likely die in more pain.

What are the reasons for these disparities?
One obvious reason is access to healthcare facilities that can provide the appropriate care–especially in rural settings. More than just facilities, many places lack well-trained oncologist and other professionals. Princess Dina Mired pointed out that many developing countries send students to the West for studies, but few come back to practice medicine in their home countries for various reasons. Even for patients who have access to healthcare and trained providers, paying for the treatment is problematic. The lecturers today cited that prior to health reforms in Mexico, almost 30% of breast cancer patients never finished cancer therapy (for which their families had already gone into severe debt) because they ran out of money. Of course, financial strain as  result of expensive treatment even with insurance can also be a problem here in the US.

There is also a divide in global funding of programs to eradicate infectious diseases vs those that target cancer in developing countries. The Bill and Melinda Gates Foundation and others have made a commendable and effective push to improve survival from infectious diseases. But why has cancer in developing countries been largely ignored by the folks holding the money bags? Perhaps it is because of the myth, which I was guilty of believing, that cancer is only a problem for wealthy countries. I hope the some of the numbers I provided above will convince you this is simply not true.

How do we overcome these disparities to reduce cancer incidence and improve cancer survival in developing countries?
Obvious solutions are improve access to health care, have better trained staff and good equipment, make health care affordable, and get more people to invest in cancer prevention and treatment for developing countries.

So, how do we do that?

What are your solutions?

 

 

References and suggested reading:
*Saving the Children — Improving Childhood Cancer Treatment in Developing Countries
Blog by Dr. Felicia Knaul
FHCRC Petri Dish blog post on HPV vaccine efficacy